MODL-21. EFFICACY OF DIFFERENT LAYOUTS IN TREATING INFRATENTORIAL TUMORS WITH TUMOR TREATING FIELDS (TTFIELDS)

Abstract TTFields are an anti-mitotic technique used to treat solid tumors by delivering low-intensity (1–4 V/cm) alternating electric fields the tumor, with frequencies between 100–500 kHz. This modality is FDA-approved for treating glioblastoma (GBM). Administration of conducted using two pairs transducer arrays placed on patient’s scalp. The layouts a key factor in determining field distribution within body. NovoTAL system array supratentorial tumors. In previous works, we suggested infratentorial layouts, as well that target entirety brain higher uniformity. However, some clinical cases, patients may have tumor and single simultaneously. such situation, question whether can both layout arises. this work, examined all GBM available (NovoTAL, whole brain). We realistic healthy patient model (Duke, ITI’S, Zurich, Switzerland) assess distributions resulting different layouts. then created maps expected dose 10 cm sized each point brain, ranked regions best groups. Our results show infra-ventricular tumors, provide than any or For supra-ventricular stronger fields. A transition zone which groups provided similar was observed well. conclude option currently presented case depends location it above large ventricles beneath them.